Research & Publications
Advancing translational Ayurvedic science — from cells to society.
SGP Research Foundation is committed to high-rigor research that bridges ancient Ayurvedic wisdom with modern scientific methods. Our work spans from cellular regeneration and metabolism to civic infrastructure and social determinants of health, enabling evidence-based change at both individual and community levels..
Overview
Dr. Ravishankar Polisetty is a distinguished clinician–scientist whose work spans a rare interdisciplinary spectrum—cardiovascular surgery, regenerative medicine, immunology, integrative Ayurveda, analytical chemistry, biotechnology, and digital health. He has authored 60+ scientific contributions, including international peer-reviewed publications, with 11 additional papers currently under review.
His scholarly footprint includes keynote addresses, conference presentations, wet-lab demonstrations, and expert lectures delivered across India, Europe, North America, and Russia, demonstrating both academic depth and global engagement.
Our Research Philosophy
We believe that transforming health in India requires simultaneous attention to biology, behavior, and the built environment.
“Healing India — From Cells to Society”
We bridge ancient Ayurvedic wisdom and modern science, while engaging with civic systems and social determinants of health. Every study is designed not only to generate evidence, but also to inform policy, shape practice, and empower communities.
Core Research Areas
• Mitral and aortic valve surgery
• Congenital cardiac repair
• Novel tissue-engineered aortic and mitral valves
• Myocardial protection and heart failure prevention
• Bio-prosthesis durability optimization
• Regenerative strategies for ischemic heart disease
• Immunomodulation in cardiomyocytes
• iNOS/NO pathways
• Immune reactions in metabolic and autoimmune disorders
• Cytokine signalling in T-cell activation
• Experimental modeling of Vata, Pitta, Kapha in Wistar rats
• Correlating dosha physiology with electrophysiology
• Ayurvedic pharmacology, phytochemistry, phytosterols
• Poly-Scientific Ayurveda & digital health analytics
• Integrative oncology and metabolic disease frameworks
• Chromatography platforms: TLC, HPTLC, HPLC, LC, GC, X-Ray crystallography
• Molecular characterization of herbal compounds
• Novel molecule discovery and biomarker evaluation
• DNA/RNA/protein microarrays
• Genomic and proteomic assays
• Cell/tissue culture
• Microfluidic devices for Ca2+ flux and signaling
• Wearable devices for personalized healthcare
• Digital dietary mapping using dosha analytics
• Reverse-engineered biopolymers for cardiovascular devices
• Smart healthcare monitors and diagnostics
1.Cardiovascular Surgery & Cardiac Regeneration
Dr. Polisetty’s core clinical and research training is in cardiovascular surgery, including CABG, valve repair and replacement, congenital heart disease surgery, and management of ischemic mitral regurgitation. His PhD work focused on the future of patients with ischemic mitral regurgitation, comparing outcomes of mitral valve replacement vs repair in 140 patients.
Key themes in this domain include:
- Outcomes in complex valvular heart disease
- Neuroprotection and myocardial protection during cardiopulmonary bypass
- Cardiac regeneration and immunomodulation as a novel strategy in ischemic heart disease and heart failure.
His publications and conference presentations cover:
- Management of left main coronary artery disease.
- Temperature management during cardiopulmonary bypass and its impact on neuropsychological outcomes.
- Bio-prosthetic valve durability and morpho-physiological aspects in valvular heart disease.
- Sutureless aortic valve replacement experience with the Trilogy Aortic Valve System.
2.Integrative Ayurveda & Systems Biology
One of Dr. Polisetty’s most distinctive contributions is the scientific exploration of Ayurveda in the language of modern physiology, electrophysiology, and systems biology.Key themes in
Highlights include:
Development of experimental models of Vata, Pitta, and Kapha in Wistar rats, correlating dietary protocols with changes in resting membrane potentials and cardiomyocyte action potentials.
Publications such as:
- “Membrane-Resting Potentials and Tridosha Prakrithi applied to Animal Behavior: A Physiological Model for the Theoretical Foundations of Ayurveda.”
- “Ayurvedic Approach to Constitutional, Biochemical, Metaphysical and Metabolic Typing of various tissues in the human body.”
- Work linking Ayurvedic dosha diets to electrophysiological properties of cells.
Applied outcomes:
- Framework for Ayurvedic dosha correlation to systems biology and cell signaling.
- Basis for personalized therapeutic and dietary recommendations under Poly Scientific Ayurveda, integrating genomic and electrophysiological insights with classical Ayurveda.
3. Immunology & Immunomodulation
As Head of the Departments of Cardiology and Immunology at ANO Research Institute of Immunopathology, Russia, Dr. Polisetty has led projects
involving:
- Calcium flux measurements in leukocytes using microfluidic devices.
- The role of P2X4 receptors, immunomodulatory phthalazine derivatives, and nitric oxide pathways in cardiac inflammation and heart failure.
- Studies on immunomodulation, iNOS and NO during inflammatory responses in cardiomyocytes, with results published in international journals.
These efforts support the development of:
- Novel immunomodulatory compounds (now covered by multiple patents).
- Integrated treatment strategies for ischemic heart disease, autoimmune conditions, and inflammatory disorders.
4. Analytical & Synthetic Chemistry
With more than 10 years of experience in analytical and synthetic chemistry, Dr. Polisetty has worked with:
- TLC, HPTLC, GC, LC, HPLC
- NMR (proton and carbon)
- X-ray crystallography
- A wide range of chromatography techniques including gas, liquid, ion-exchange, size exclusion, affinity, reverse-phase, pyrolysis-gas, 2D chromatography, and FPLC.
This expertise supports:
- Standardization of herbal formulations
- Isolation and structural characterization of novel bioactive compounds
- Quality control of investigational drugs and device-coated biopolymers.
5. Biotechnology, Genomics & Regenerative Medicine
Dr. Polisetty’s biotechnology experience covers:
- Genetic mapping
- DNA, RNA, and protein microarrays
- Cell and tissue culture
- Advanced proteomic and genomic technologies
Key applications:
- Evaluating gene expression changes under herbal treatment (e.g., effects of Terminalia arjuna on MCIP1, Smilax glabra on Her2neu).
- Exploring stem cell migration and immunomodulation in heart disease and cardiac regeneration.
- Preclinical work on regenerative formulations for cardiomyocytes and neuronal tissue.
6. Digital Health & Medical Devices
From his clinical and integrative research, Dr. Polisetty has contributed to advanced health analytics and medical devices,
particularly:
- Conceptualization and development of Docture-Poly, a device that uses pulse and physiological signals to provide continuous health insights, integrating Ayurvedic and modern parameters.
- Devices that quantify organ-specific action potentials and aim to function as a digital doctor assistant, feeding into personalized health recommendations.
These devices have been showcased at events like:
- GITEX Global 2023, Dubai
- India Start-Up Festival
- IIT Hyderabad E-Summit (Carrefour) and other innovation platforms.
Key Research Appointments & Collaborations
External Research Consultant – Johns Hopkins University, USA
Dr. Ravi Shankar Polisetty has acted as an External Research Consultant to Johns Hopkins University since 2013, contributing to:
- Pre-clinical study design for a novel compound targeting LVH and aortic thickening in chronic hypertension.
- Method development for HPLC assays, accelerated and real-time stability studies, solubility, plasma protein binding, permeability, and metabolic stability.
- Toxicology: single-dose acute and repeated-dose toxicity in animal models.
- Preparation for human trials under regulatory oversight of the Ministry of Health (India) and global requirements.
He has also contributed to the development of novel biopolymers for drug-eluting stents (DES) and has experience with coordination involving regulators like the FDA.
Clinical Trials & Industry Research
✤ Arbor Surgicals, California, USA
As a Clinical Study Coordinator, he oversaw clinical trials for bovine pericardial heart valves later acquired by Medtronic in a USD 320M deal. Responsibilities included protocol development, investigator and site selection, monitoring, data management, and regulatory submissions.
✤ Panacea Contract Research Consulting Limited, Canada
As Director R&D, he led preclinical and clinical research projects, including:
- Reverse engineering of artificial aortic valves
- Discovering new pharmacological actions of phthalazine and phytosterol derivatives on P2X4 and PARP receptors
- Toxicology, pharmacology and regulatory strategy for multiple investigational products.
✤ Sai Ganga Panakeia (India & Russia)
As Chief Executive and Director of R&D, he:
- Directed trials on Atherolyzin™, a polyherbal formulation for ischemic heart disease, under Indian regulatory supervision (CDCSO & DCGI).
- Led genomic evaluation of herbal components and ongoing biotechnological projects to enhance formulation efficacy.